HORDB

ID: hor005231
Uniprot ID: Q28934
Protein name: Islet amyloid polypeptide
Gene name: IAPP
Organism: Saguinus oedipus (Cotton-top tamarin)
Family: Calcitonin family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Saguinus (genus), Callitrichinae (subfamily), Cebidae (family), Platyrrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Function: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-Q28934-F1.pdb

hor005231_AF2.pdb

hor005231_ESM.pdb

Mass:	389282	Formula:	C140H224N44O47S2
Absent amino acids:	EKQWY	Common amino acids:	S
pI:	8.56	Basic residues:	3
Polar residues:	16	Hydrophobic residues:	10
Hydrophobicity:	-9.69	Boman Index:	-5293
Half-Life:	1.4 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	67.19
Instability Index:	4472.5	Extinction Coefficient cystines:	0
Absorbance 280nm:	0